A practical two-step procedure for the preparation of enantiopure pyridines: Multicomponent reactions of alkoxyallenes, nitriles and carboxylic acids followed by a cyclocondensation reaction

• Christian Eidamshaus,
• Roopender Kumar,
• Mrinal K. Bera and
• Hans-Ulrich Reissig

Beilstein J. Org. Chem. 2011, 7, 962–975, doi:10.3762/bjoc.7.108

• substrate scope and leads to differentially substituted enantiopure pyridines in good to moderate yields. The preparation of diverse substituted lactic acid derived pyrid-4-yl nonaflates is described. Additional evidence for the postulated mechanism of the multicomponent reaction is presented. Keywords

• : allenes; enantiopure pyridines; ketoenamides; multicomponent reactions; nonaflates; Introduction The pyridine core is ubiquitous in pharmacologically active agents, agrochemicals and natural products [1][2][3][4][5]. The HMG-CoA reductase inhibitors Glenvastatin and Cerivastatin are exemplarily mentioned